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A. Flury, L. Aljayousi, S. Aziz, H.-J. Park, M. Khakpour, C. Sandberg, F. G. Ibáñez, O. Braniff, P. Deme, J. D. McGrath, T. Ngo, J. Mechler, D. M. Ramirez, D. Avnon-Klein, J. W. Murray, J. Liu, N. J. Haughey, S. Werneburg, M.-È. Tremblay, P. Ayata. Integrated Stress Response Associated with Dark Microglia Promotes Microglial Lipogenesis and Contributes to Neurodegeneration. preprint.
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T. E. Faust, Y.-H. Lee, C. D. O’Connor, M. A. Boyle, G. Gunner, A. Badimon, P. Ayata, A. Schaefer, D. P. Schafer. Microglia-Astrocyte Crosstalk Regulates Synapse Remodeling via Wnt Signaling. preprint. .
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W. T. Ralvenius, A. E. Mungenast, H. Woolf, M. M. Huston, T. Z. Gillingham, S. K. Godin, J. Penney, H. P. Cam, F. Gao, C. G. Fernandez, B. Czako, Y. Lightfoot, W. J. Ray, A. Beckmann, A. M. Goate, E. Marcora, C. Romero-Molina, P. Ayata, A. Schaefer, E. Gjoneska, et al. A Novel Molecular Class That Recruits HDAC/MECP2 Complexes to PU.1 Motifs Reduces Neuroinflammation. Journal of Experimental Medicine, 2023, 220 (11), e20222105. DOI: https://doi.org/10.1084/jem.20222105.
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P. Ayata, I. Amit, C. M. Cuda. Editorial: Microglia in Neuroinflammation. Front. Immunol., 2023, 14, 1227095. DOI: https://doi.org/10.3389/fimmu.2023.1227095.
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Using chemogenetic models, microglia depletion, and pharmacology, this paper revealed a previously unknown role for microglia, providing negative feedback to active neurons to curb their hyper excitability.
A. Badimon, H. J. Strasburger, P. Ayata, X. Chen, A. Nair, A. Ikegami, P. Hwang, A. T. Chan, S. M. Graves, J. O. Uweru, C. Ledderose, M. G. Kutlu, M. A. Wheeler, A. Kahan, M. Ishikawa, Y.-C. Wang, Y.-H. E. Loh, J. X. Jiang, D. J. Surmeier, S. C. Robson, et al. Negative Feedback Control of Neuronal Activity by Microglia. Nature, 2020, 586 (7829), 417–423. DOI: https://doi.org/10.1038/s41586-020-2777-8.
