This paper introduced 5hmC as a stable activation mark and supported a novel epigenetic model by 5hmC-MeCP2 interaction and a new perspective on Rett syndrome pathology.
M. Mellén, P. Ayata*, S. Dewell, S. Kriaucionis, N. Heintz. MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System. Cell, 2012, 151 (7), 1417–1430. DOI: https://doi.org/10.1016/j.cell.2012.11.022. (* co-first author)